Endocrine Abstracts

Introduction: Data on transsphenoidal surgery (TSS) and effect of somatostatin analog therapy (SSA) in acromegaly different among medical centers. We analyzed the data on TSS, SSA and their combination in acromegalic patients of Moscow region.Design: In this study 117 acromegalic patients (25 males and 92 females, 55.0 (IQR 44 – 62) years) were eligible for participation, of whom 34 were newly-diagnosed aromegaly (NA group) (macroadenoma (macro)- 80...

Background: Patients with Cushing’s syndrome (CS) have a lot of complications due to chronic exposure of cortisol.Aim: To reveal specific changes of cardiovascular system in patients with CS.Material and methods: i) Six patients with CS (five females, one male, 47.1±1.5 years old), duration of CS 3.4±1.2 years, ii) 19 healthy patients (48.1±3.0 years old), and iii) ten patients with ischemic heart disease (IHD) ...

There are some data concerning high prevalence of infrasellar extension of somatotropinomas. To reveal any differences expansion of pitutary macroadenomas with various hormonal secretion, we have analyzed MRI data of 175 pituitary macroadenomas: 87 non-functioning adenomas (NFAs), 48 prolactinomas, 43 somatotropinomas. The sizes of pituitary tumour (vertical, sagittal, frontal): NFAs 24 (17.5; 34.5)mm, 23 (17.4; 28) mm, 23 (18; 30) mm; prolactinomas 21 (15; 31) mm, 20 (16; 30)...

We analysed BMI of 270 female patients: 148 with hyperprolactinaemia (non-tumoural hyperprolactinaemia, n=46; microadenomas, n=56; and macroadenomas, n=46), 55 with isolated central hypogonadism, 67 with hypopituitarism. Additionally, 53 healthy women of reproductive age and 51 postmenopausal women were examined. In patients with hyperprolactinaemia median prolactin levels were 1547 (1124; 2185), 1490 (1050; 2280), and 3100 (1790; 18840) mE/l, accord...

We investigated 49 patients with non-functioning pituitary macroadenomas: 11 males, 38 females, age 31–78 y.o. (median 61). Extrasellar tumor expansion was observed in 46 (93.9%) patients: suprasellar – 41 (83.7%), laterosellar 27 (55.1%), and infrasellar 18 (36.7%) patients; combined types of extrasellar expansion – 36 (73.5%) patients.Prolactin levels (PRL) varied from 115 to 1495 mU/l, hyperprolactinemia was found in 27 (55.1%) patients...

Background: Dulaglutide has been approved as a hypoglycemic agent for the treatment of patients with T2DM. A positive effect on carbohydrate metabolism and body weight was shown in RCT.It was found that GLP-1 agonists may prevent the progression of NAFLD directly affecting lipid metabolism and inflammation.Aim: To assess the effect of dulaglutide on carbohydrate and hepatic metabolism in patients with T2DM and NAFLD in real clinica...

The aim of the study is to compare efficacy of RAI in patients with Graves disease using different methods calculation of optimum therapeutic activity.Methods: About 60 patients (50 women, 10 men, mean age 44.8±11.8 years) with Graves decease were treated with RAI. The treatment with ATD was cancel 10 days before RAI to restore the iodine intake by thyroid gland. Therapeutic activity was determent individually 1) with applied the special formula in ...

Aim: To assess the accuracy of the TBSRTC in verification of thyroid carcinoma in the region of Moscow county.Material and methods: A retrospective study of data from electronic medical notes of 1,675 patients who underwent fine needle aspiration biopsy of nodular thyroid glands in 2016. The cytological conclusion was evaluated in accordance with the TBSRTC. In cases of surgical treatment (thyroidectomy or hemithyroidectomy) the cytological diagnosis was...

Introduction: Acromegaly is a rare chronic disease caused by growth hormone (GH) and insulin-like growth factor 1 type (IRF-1) excess. However, reaching biochemical control of the disease does not always guarantee the improvement of symptoms that play a significant role in the quality of life associated with human health (HRQoL), in particular, patients with acromegaly.Goal: To investigate the quality of life in patients with acromegaly in the Moscow reg...

Background: Pregnancy occurs rarely in Cushing’s syndrome (CS), slightly over 150 cases have been reported in the literature. The risk of maternal morbidity and a poor fetal outcome is significant when CS coexists with pregnancy. CS may be difficult to detect clinically and laboratory because of the hormonal changes and pathological comorbidities associated with normal pregnancy.Material and methods: A case of CS that was diagnosed and treated durin...